Tuberculosis Publications (1999-2002)

The Crystal Structure of Mycobacterium tuberculosis Alkylhydroperoxidase AphD, a Potential Target for Antitubercular Drug Development. Nunn, C. M., Djordjevic, S., Hillas, P. J., Nishida, C., and Ortiz de Montellano, P. R. (2002) J. Biol. Chem., 277, 20033-20040. HTML, PDF

The Antituberculosis Drug Ethionamide is Activated by a Flavoprotein Monoxygenase. Vannelli, T., Dykman, A., and Ortiz de Montellano, P. R. (2002) J. Biol. Chem., 277, 12824-12829. HTML, PDF

The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moenne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 14112-14123.  HTML, PDF

The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis. Hillas, P.J., Soto del Alba, F., Oyarzabal, J., Wilks, A., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 18801-18809 HTML, PDF

Reduction of Peroxides and Dinitrobenzenes by Mycobacterium tuberculosis Thioredoxin and Thioredoxin Reductase. Zhang, Z., Hillas, P. J., and Ortiz de Montellano, P. R. (1999) Arch. Biochem. Biophys. 363, 19-26. HTML  PDF