Antihypertensive Effect of Mechanism-Based Inhibition of Renal Arachidonic Acid w-Hydroxylase Activity. Xu, F., Pak, W., Su, P., Straub, W. O., Ortiz de Montellano, P. R., and Kroetz, D. L. (2002) Am. J. Physiol.: Regulatory, Integrative and Comparative Physiology. in press.
Aromatic Stacking as a Determinant of the Thermal Stability of CYP119 from Sulfolobus solfataricus. Puchkaev, A. V., Koo, L. S. K., and Ortiz de Montellano, P. R. (2002) Arch. Biochem. Biophys. in press.
Cytochrome P450 3A4-Mediated Oxidative Conversion of a Cyano to an Amide Group in the Metabolism of Pinacidil. Zhang, Z., Li, Y., Stearns, R. A., Ortiz de Montellano, P. R., Baillie, T. A., and Tang, W. (2002) Biochemistry, 41, 2712-2718. HTML, PDF.
Autocatalytic Mechanism and Consequences of Covalent Heme Attachment in the Cytochrome P4504A Family. Lebrun, L. A., Hoch, U., and Ortiz de Montellano, P. R. (2002) J. Biol. Chem., 277, 12755-12761. HTML, PDF
Covalent Attachment of the Heme Prosthetic Group in the CYP4F Cytochrome P450 Family. LeBrun, L. A., Xu, F., Kroetz, D. L., and Ortiz de Montellano, P. R. (2002) Biochemistry , 41, 5931-5937. HTML, PDF
Revisiting the Mechanism of P450 Enzymes Using the Radical Clocks Norcarane and Spiro[2,5]bicyclooctane. Auclair, K., Hu, Z., Little, D. M., Ortiz de Montellano, P. R., and Groves, J. T. (2002) J. Am. Chem. Soc., 124, 6020-6027. HTML, PDF
Ehanced Electron Transfer and Lauric Acid Hydroxylation by Site-Directed Mutagenesis of CYP199. Koo, L. S., Immoos, C. E., Cohen, M. S., Farmer, P. J., and Ortiz de Montellano, P. R. (2002) J. Am. Chem. Soc., 124, 5684-5691. HTML, PDF
Cytochrome P450cin (CYP176A): Isolation, Expression, and Characterization. Hawkes, D. B., Adams, G., Burlingame, A., Ortiz de Montellano, P. R., and De Voss, J. J. (2002) J. Biol. Chem., 277, 27725-27732. HTML, PDF
Reversible Pressure Deformation of a Thermophilic Cytochrome P450 Enzyme (CYP119) and its Active-Site Mutants. Tschirret-Guth, R.A., Koo, L.S., Hui Bon Hoa, G., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc. 123, 3412-3417. HTML, PDF
Covalently-linked Heme in Cytochrome P4504A Fatty Acid Hydroxylases. Hoch, U., and Ortiz de Montellano, P.R. (2001) J. Biol. Chem. 276, 11339-11346. HTML, PDF
Roles of the Proximal Heme Thiolate Ligand of Cytochrome P450cam. Auclair, K., Moenne-Loccoz, P., and Ortiz de Montellano, P.R. (2001) J. Am. Chem. Soc. 123, 4877-4885. HTML, PDF
Reactivities of Organic Phase Biosensors 3: Electrochemical Study of Cytochrome P450cam Immobilised in a Methyltriethoxysilane Sol-Gel. Iwuoha, E.I., Kane, S., Ania, C.O., Smyth, M.R., Ortiz de Montellano, P.R., and Fuhr, U. (2000) Electroana lys is. 12, 980-986. Abstract, PDF
An Ala245Thr Mutation Conveys on Cytochrome P450eryF the Ability to Oxidize Alternative Substrates. Xiang, H., Tschirret-Guth, R.A., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem. 275, 35999-36006. HTML, PDF
Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus. Yano, J.K., Koo, L.S., Schuller, D.J., Li, H., Ortiz de Montellano, P.R., and Poulos, T.L. (2000) J. Biol. Chem 275, 31086-31092. HTML, PDF
Molecular Basis for the w-Regiospecificity of the CYP4A2 and CYP4A3 Fatty Acid Hydroxylases. Hoch, U., Falck, J.R., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem 275, 26952-26958. HTML, PDF
The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus. Koo, L.S., Tschirret-Guth, R.A., Straub, W., Moenne-Loccoz, P., Loehr, T.M., and Ortiz de Montellano, P.R. (2000) J. Biol. Chem 275, 14112-14123. HTML, PDF
Protein Control of the Formation and Decomposition of CYP119 and CYP110 Aryl-Iron Complexes. Tschirret-Guth, R.A., Koo, L.S., and Ortiz de Montellano, P.R. (2000) J . Biol. Inorg. Chem. 5, 204-212. Abstract, PDF
Omega-Hydroxyceramides are Required for Covalently-Bound Lipid Envelope (CLE) Formation and Normal Epidermal Permeability Barrier Function. Behne, M., Uchida, Y., Seki, T., Ortiz de Montellano, P.R., Elias, P.M., and Holleran, W.M. (2000) J. Invest. Dermatol. 114, 185-192. HTML, PDF
Structural Determination of the Substrate Specificities and Regioselectivities of the Rat and Human Fatty Acid w -Hydorxylases. Hoch, U., Zhang, Z., Kroetz, D.L., and Ortiz de Montellano, P.R. (2000) Arch. Biochem. Biophys. 373, 63-71. Abstra ct, PD F
Trifluoromethyldiazirinylphenyldiazenes: New Hemoprotein Active Site Probes. Tschirret-Guth, R. A., Medzihradszky, K. F., and Ortiz de Montellano, P. R. (1999) J. Am. Chem. Soc. 121, 4731-4737. HTML, PDF
Deuterium Magic Angle Spinning Studies of Substrates Bound to Cytochrome P450. Lee, H., Ortiz de Montellano, P.R., and McDermott, A.E. (1999) Biochemistry 38, 10808-10813. HTML
The Catalytic Site of Cytochrome P4504A11 (CYP4A11) and Its L131F Mutant. Dierks, E. A., Zhang, Z., Johnson, E. F., and Ortiz de Montellano, P. R. (1998) J. Biol. Chem 273, 23055-23061. HTML PDF
The Substrate Specificity of Cytochrome P450cam . Zhang, Z., Sibbesen, O., Johnson, R. A., and Ortiz de Montellano, P. R. (1998) Bioorg. Med. Chem 6, 1501-1508. HTML, PDF
Cytochrome P450cam Substrate Specificity: Relationship Between Structure and Catalytic Oxidation of Alkylbenzenes. Sibbesen, O., Zhang, Z., and Ortiz de Montellano, P. R. (1998) Arch. Biochem. Biophys. 353, 285-296. Abstract PDF
Drug Metabolism Biosensors: Electrochemical Reactivities of Cytochrome P450cam Immobilized in Synthetic Vesicular Systems. Iwuoha, E., Joseph, S., Zhang, Z., Smyth, M. R., Fuhr, U., and Ortiz de Montellano, P. R. (1998) J. Pharm. Biomed. Analysis 17 (6-7), 1101-1110.
Pressure-Induced Deformations of the Cytochrome P450cam Active Site. Tschirret-Guth, R., Ortiz de Montellano, P. R., and Hui Bon Hoa, G. (1998) J. Am. Chem. Soc., 120, 3590-3596. HTML PDF
Glu-320 and Asp-323 are Determinants of the CYP4A1 Hydroxylation Regiospecificity and Resistance to Inactivation by 1-Aminobenzotriazole. Dierks, E. A., Davis, S. C., and Ortiz de Montellano, P. R. (1998) Biochemistry 37, 1839-1847. HTML PDF
Substrate Docking Algorithms and Prediction of the Substrate Specificity of Cytochrome P450cam and its L244A Mutant. De Voss, J. J., Sibbesen, O., Zhang, Z. P., and Ortiz de Montellano, P. R. (1997) J. Am. Chem. Soc. 119, 5489-5498. HT ML PDF
Putidaredoxin Reductase-Putidaredoxin-Cytochrome P450cam Triple Fusion Protein. Construction of a Self-Sufficient Escherichia coli Catalytic System. Sibbesen, O., De Voss, J. J., and Ortiz de Montellano, P. R. (1996) J. Biol. Chem 271, 22462-22469. HTML PDF
Active Site Topologies of CYP2D6 and Its Aspartate-301 -> Glutamate and Asparagine Mutants. Mackman, R., Tschirret-Guth, R. A., Smith, G., Hayhurst, G. P., Ellis, S. W., Lennard, M. S., Tucker, G. T., Wolf, C. R., and Ortiz de Montellano, P. R. (1996) Arch. Biochem. Biophys. 331, 134-140. Abstract PDF
Oxidation of w-Oxofatty Acids by Cytochrome P450BM-3 (CYP102). Davis, C., Sui, Z., Peterson, J. A., and Ortiz de Montellano, P. R. (1996) Arch. Biochem. Biophys 328, 35-42. Abstract PDF
Active Site Topology of Human Cytochrome P450 2E1. Mackman, R., Guo, Z., Guengerich, F. P., and Ortiz de Montellano, P. R. (1996) Chem. Res. Toxicol. 9, 223-226. HTML P DF
Active Site Topology of Bovine Cholesterol Side-Chain Cleavage Cytochrome P450 (P450scc) and Evidence for Interaction of Tyrosine 94 with the Side-Chain of Cholesterol. Pikuleva, I. A., Mackman, R. L., Kagawa, N., Waterman, M. R., and Ortiz de Montellano, P. R., (1995) Arch. Biochem. Biophys. 322, 189-197.
Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam. De Voss, J. J., and Ortiz de Montellano, P. R. (1995) J. Am. Chem. Soc. 117, 4185-4186.
Thioanisole Sulfoxidation by Cytochrome P450cam (CYP101): Experimental and Calculated Absolute Stereochemistries. Fruetel, J., Chang, Y.-T., Collins, J., Loew, G., and Ortiz de Montellano, P. R. (1994) J. Am. Chem. Soc. 116, 11643-11648.
Relationship of Active Site Topology to Substrate Specificity for Cytochrome P450terp (CYP108). Fruetel, J. A., Mackman, R. L., Peterson, J. A., and Ortiz de Montellano, P. R. (1994) J. Biol. Chem 269, 28815-28821.
Endogenous P450 Metabolites of Arachidonic Acid Modulate Tubuloglomerular Feedback. Zou, A.-I., Imig, J. D., Ortiz de Montellano, P. R., Sui, Z., Falck, J. R., and Roman, R. J. (1994) Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35) F934-F941.
Cytochrome P450 Inhibitors Alter Afferent Arteriolar Responses to Elevations in Pressure. Imig, J. D., Zou, A.-I., Ortiz de Montellano, P. R., Sui, Z., and Roman, R. J. (1994) Am. J. Physiol. 266 (Heart Circ. Physiol. 35) H1879-H1885.
Differential Roles of Glu318 and Thr319 in Cytochrome P450 1A2 Catalysis Supported by NADPH-Cytochrome P450 Reductase and tert-Butyl Hydroperoxide. Hiroya, K., Murakami, Y., Shimizu, T., Hatano, M., and Ortiz de Montellano, P. R. (1994) Arch. Biochem. Biophys. 310, 397-401.
Effects of 17-Octadecynoic Acid, a Suicide-Substrate Inhibitor of Cytochrome P450 Fatty Acid w-Hydroxylases, on Renal Function in Rats. Zou, A.-P., Ma, Y.-W., Sui, Z., Ortiz de Montellano, P. R., Clark, J. E., Masters, B. S. S., and Roman, R. J. (1994) J. Pharmacol. Exp. Therap. 268, 474-481.
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